Robert C. Chang                                                                               

30 S. 22nd Street Apt. 22       

Philadelphia, PA, 19103                                                                                               

Lab No.:         1 215 895 6688                                                                                                                                          

Cell No.:        1 856 625 8818

Email:      rcc34@drexel.edu

 

 

EDUCATION:

 

B.S., Department of Chemical Engineering, University of Pennsylvania, Philadelphia, PA

Graduated Cum Laude

August 1996 – June 2000

 

Medical Student (Year 1 and 2), Albert Einstein College of Medicine, Bronx, NY

August 2000 – June 2002

Medical Student (Year 3), Albert Einstein College of Medicine, Bronx, NY

July 2002 – October 2002, July 2003 – December 2004

 

Ph.D. Candidate, Department of Mechanical Engineering, Drexel University, Philadelphia, PA

January 2005 – present (expected graduation date: March 2009)

Dissertation Title: Direct Cell Writing 3D Liver Micro-organ for Drug Metabolism Study

Ph.D. Advisor:  Dr. Wei Sun, Albert Soffa Chair Professor

 

EXPERIENCE:

 

01/2005 – present    Graduate Research Assistant, Computer Aided Tissue Engineering Laboratory, Department of Mechanical Engineering, Drexel University

·         Conducted collaborative research work with NASA-JSC in which a proprietarily developed direct cell writing biomanufacturing system is implemented to integrate with a microfluidic tissue chamber to create a reproducible, high-fidelity 3D micro-organ for high-throughput in vitro drug metabolic and toxicological screening.

·         Participated in NSF-funded project in computer-aided tissue engineering for the design and manufacture of reproducible tissue scaffolds or temporary synthetic extracellular matrices for cell seeding and subsequent implantation for application in regenerative medicine.

 

10/2008 – present    Adjunct Instructor, Department of Mechanical Engineering, Drexel University

·         Role: taught course for MEM 201: Introduction to CAD (10/2008 – 12/2008)

·         Role: gave lectures for MEM 435: Introduction to CAD/CAM

(1/2008 – 3/2008)

 

1/2005 – present      Graduate Teaching Assistant, Department of Mechanical Engineering, Drexel University

·         Role: taught labs for MEM 201: Introduction to CAD and MEM 435: Introduction to CAD/CAM  course sequences (every term)

 

11/2002 – 06/2003    Research Fellow, Department of Radiation Oncology, Albert Einstein College of Medicine, Advisor: Dr. Chandan Guha

·         Conducted research on the use of a quantitative three-dimensional phosphorus-31 nuclear magnetic resonance (31P-NMR) chemical shift imaging (CSI) as a noninvasive tool for the assessment of liver cell regeneration and radiation-induced hepatic injury.

 

06/2000 – 06/2003    Medical Volunteer, Community Health Outreach Free Clinic, Bronx, NY

·         Participated in student-run Einstein’s Community Health Outreach (ECHO) to provide medical care, health education, and social services to uninsured.

 

06/1999 – 06/2000    Educational Software Developer, Department of Chemical Engineering, University of Pennsylvania, Advisor: Dr. Warren Seider

·         Developed and released a multimedia module CD-ROM to analyze aspects of chemical process design and control by training students in use of industrial software packages including ASPEN PLUS, HYSIS, and PRO/II.

 

06/1997 – 06/1999    Undergraduate Research Assistant, Division of Trauma and Critical Care, Hospital of the University of Pennsylvania, Advisors: Dr. Michael Rotondo and Dr. Patrick Reilly

·         Conducted data abstraction and statistical analyses, literature searches, medical record reviews, research design and writing. Collected data for AAST Multi-Institutional Trial of Penetrating Esophageal Injuries, Multi-Institutional Trial on Penetrating and Blunt Renal Injuries, and worked with Philadelphia City Medical Examiner on Six-Year Study of Trends for Non-Firearm Homicide in the Urban Setting.

 

PUBLICATIONS (Journal):

 

1.         Chang R., Nam J., and Sun W. “Direct Cell Writing of 3D Micro-organ for In Vitro Pharmacokinetic Model,” Tissue Engineering Part C, 14(2), 157-169, 2008.

2.         Chang R., Nam J., and Sun W. “Computer-Aided Design, Modeling, and Freeform Fabrication of Micro-organ Flow Patterns for Pharmacokinetic Study,” CAD Applications, Vol. 5, p. 21-29, 2008.

3.         Chang R., Nam J., and Sun W. “Effects of Dispensing Pressure and Nozzle Diameter on Cell Survival from Solid Freeform Fabrication-based Direct Cell Writing,” Tissue Engineering, 14(1): 41-48, 2008.

4.         Chang R., Emami K., Jeevarajan A., Wu H., and Sun W. “Direct Cell Writing of 3D Micro-organ for Drug Metabolism Studies,” Biofabrication, in press.

5.         Shor L., Guceri  S., Chang R., Sun W., Gordon J., Kang Q., Hartstock L., and An Y. “Precision Extruding Deposition (PED) Fabrication of Poly-e-Caprolactone (PCL) Scaffolds for Bone Tissue Engineering,” Tissue Engineering Part C, in press.

6.         Schwab C., Frankel H., Shapiro M., Chang R., et al. Penetrating Esophageal Injuries: Multicenter Study of the American Association for the Surgery of Trauma”, Journal of Trauma 50:2, 2001.

7.         Reilly P., Chang R., Schwab C., McDonald G., Rotondo M, Zonies D, Kauder D, Bar C., Branas, C., and Richmond T.Urban Non-Firearm Homicides: A Six Year Perspective”, Journal of Trauma 47:1173, 1999.

 

PUBLICATIONS (Book Chapter):

 

1.          Chang R., Emami K., Jeevarajan A., Wu H., and Sun W., “Microprinting of Liver Micro-organ for Drug Metabolism Study”, Edited by Ali Khademhosseini, Biological Microarray, in press.

2.          Chang R., Nam J., Holtorf H., Emami K., Gonda S., Jeevarajan A., Wu H., and Sun W. “A Case Study on 3D Bioprinted Liver Micro-organ as a Drug Metabolism Model”, Edited by Ola Harrysson, SME Rapid Technologies/Additive Manufacturing for Medical Applications, in press.

3.          Yildirim E., Ayan H., Chang R., Sperling M., Gorniak R., Guceri, S. and Sun W. “Case 3.6: RP Assisted Mapping Epileptic Regions of Brain for Invasive Intracranial Electroencephalography”, Edited by Ola Harrysson, SME Rapid Technologies/Additive Manufacturing for Medical Applications, in press.

 

PUBLICATIONS (Conference Proceedings):

 

1.         Chang R., Liu Q., Lau W., and Sun W. “3D Cell Culture for Enhancement of Cell Function,” The American Society for Cell Biology (ASCB) in San Francisco, CA, December 13-17, 2008.

2.         Chang R., Liu Q., Lau W., and Sun W. 3D Scaffolds for Enhanced Cell Culture and Tissue Engineering Applications”, Tissue Engineering and Regenerative Medicine North America, San Diego, CA, Decmeber 9-13, 2008.

3.         Chang R., Nam J., Jeevarajan A., Wu H. and Sun W., “Direct Cell Writing of 3D Tissue Micro-organs for Drug Metabolism Study,” the 13th International Biotechnology Symposium & Exhibition (IBS-2008), Dalian, China, Oct. 12-17, 2008.

4.         Chang R., Nam J., Morss-Clyne A., and Sun W., “Direct Cell Writing of Cell Encapsulated 3D Liver Tissue Constructs Patterned With Endothelial Cells”, 8th World Biomaterials Congress, Amsterdam, Holland, May 28-23, 2008.

5.         Holtorf  H., Leslie J., Chang R., Nam J., Culbertson C., Sun W., Gonda S., “Development of a Three-Dimensional Tissue-on-a-Chip Micro-Organ Device for Pharmacokinetic Analysis”, the 47th Annual Meeting of the American Society for Cell Biology, Washington, DC, December 1-5, 2007.

6.         Chang R., Nam J., Holtorf H., Jeevarajan A., Gonda S., Culbertson C., and Sun W. “Biofabrication of Liver Tissue Constructs on a Microfluidic Platform for Pharmacokinetic Study”, Proceedings of the International Manufacturing Science and Engineering, October 15-18, 2007, Atlanta, GA, USA.

7.         Chang R., Nam J., Holtorf H., Jeevarajan A., Gonda S., Culbertson C. and Sun W., “Biofabrication of Liver Tissue Constructs on a Microfluidic Platform for Pharmacokinetic Study”, ASME International Manufacturing Science and Engineering 2007, October 15-18, 2007, Atlanta, Georgia, USA.

8.         Chang R., Nam J., and Sun W. “Direct Cell Writing for Freeform Biofabrication of 3D Pharmacokinetic Models”, Proceedings of 18th Solid Freeform Fabrication Symposium, August 6-8, 2007, Austin, TX, USA.

9.         Chang R., Nam J., and Sun W. “Freeform Biofabrication of Hepatocellular Tissue Constructs as an In Vitro Physiological Model”, Flexible Automation and Intelligent Manufacturing (FAIM), June 18-20, 2007, Philadelphia, PA, USA.

10.      Chang R., Sun W., Culbertson C., Holtof H., and Gonda S.Design and Modeling of Flow Patterns for Cell Encapsulated 3D Liver Tissue-on-chip as a Pharmacokinetic Study Platform”, Tissue Engineering and Regenerative Medicine North America, June 13-16, 2007, Toronto, ON, Canada.

11.      Chang R., Nam J., Culbertson C., Holtorf H., Jeevarajan A. and Sun W., “Computer-Aided Freeform Bioprinting of 3D Tissue Constructs for Pharmacokinetic Study”,  the 3rd International Symposium on Bioprinting and Biofabrication 2006, November 21-22, 2006, Kawasaki, Japan.

12.      Chang R., Starly B., and Sun W.Integration of Liver Encapsulated Alginate Hydrogels onto a Microfluidic Platform Using Freeform Fabrication”, Proceedings of 17th Solid Freeform Fabrication Symposium, August 14-16th, 2006, Austin, TX, USA.

13.      Chang R., Starly B., Culbertson C., Holtof H., Gonda S., and Sun W.Development of an in vitro Micro-organ Model for Pharmacokinetic Microanalysis”, Proceedings of 2006 IEEE Northeast Bioengineering Conference, April 1-2, 2006, Lafayette College, Easton, PA, USA.

14.      Starly B., Chang R., Sun W., Culbertson C., Holtof H., and Gonda S.Bioprinted Tissue-on-chip Application for Pharmacokinetic Studies”, World Congress on Tissue Engineering and Regenerative Medicine, April 24-27, 2006, Pittsburgh, PA, USA.

15.      Starly B., Chang R., Sun W.Fabrication of Hepatocyte Encapsulated Poly-Ethylene Glycol Hydrogels Using UV-Photolithography”, Proceedings of 17th Solid Freeform Fabrication Symposium, August 14-16th, 2006, Austin, TX, USA.

 

ORAL PRESENTATIONS:

 

1.      Koerner Family Fellowship Symposium 2008, February 20, 2008, Drexel University, Philadelphia, PA, USA.

2.      Holtorf H., Leslie J., Chang R., Nam J., Culbertson C., Sun W., Gonda S., “Development of a Three-Dimensional Tissue-on-a-Chip Micro-Organ Device for Pharmacokinetic Analysis”, the 47th Annual Meeting of the American Society for Cell Biology, December 1-5, 2007, Washington, DC, USA.

3.      Chang R., Nam J., and Sun W. “Freeform Biofabrication of Hepatocellular Tissue Constructs as an In Vitro Physiological Model”, Flexible Automation and Intelligent Manufacturing (FAIM), June 18-20, 2007, Philadelphia, PA, USA.

4.      Chang R., Sun W., Culbertson C., Holtof H., and Gonda S.Design and Modeling of Flow Patterns for Cell Encapsulated 3D Liver Tissue-on-chip as a Pharmacokinetic Study Platform”, Tissue Engineering and Regenerative Medicine North America, June 13-16, 2007, Toronto, ON, Canada.

5.      Chang R., Starly B., and Sun W.Integration of Liver Encapsulated Alginate Hydrogels onto a Microfluidic Platform Using Freeform Fabrication”, 17th Solid Freeform Fabrication Symposium, August 14-16th, 2006, Austin, TX, USA.

6.      Chang R., Starly B., Culbertson C., Holtof H., Gonda S., and Sun W.Development of an in vitro Micro-organ Model for Pharmacokinetic Microanalysis”, 2006 IEEE Northeast Bioengineering Conference, April 1-2, 2006, Lafayette College, Easton, PA, USA.

 

PATENTS:

 

·            Patent Pending: “Bioprinting Three-Dimensional Polymeric Hydrogel Structures Onto Microscale Tissue Analog Devices for Pharmacokinetic Study,” D2027/20052 (co-inventors Binil Starly, Jae Nam, Wei Sun).

·            Patent Pending: “Micro-Organ Device,” NASA Case No. MSC-23988-1 (co-inventors Steve Gonda, Heidi Holtorf, Binil Starly, Jae Nam, Wei Sun).

 

EXPERTISE:

 

§     CAD software packages – Expert in AutoCAD, SolidWorks, Pro/Engineer

§     Finite Element Analysis/Fluid software packages – Competent in ANSYS, ProMechanica, ABAQUS, Star-CD, Comsol Multiphysics

§     Rapid Prototyping Manufacturing Processes – Expert in 3D Printing and Direct Cell Writing, Competent in Precision Extrusion Deposition, Electrospinning

§     Cell Culture – Expert in bone and liver bioassays, fluorescent microscopy, cytofluoremeter

§     Medical Image Processing & Reverse Engineering Software – Competent in MIMICS, GEOMAGICS

§     Micro Fabrication Technologies – Competent in photolithography, MEMS devices

§     Industrial chemical engineering software – Competent in ASPEN PLUS, HYSIS, and PRO/II

§     DSP Microprocessor – Competent in Texas Instrument’s 2780 DSP for embedded control

§     Certification in E.M.T., C.P.R., and Basic Life Support

 

AWARDS:

 

BP Young Scientists and Students Award (YSSA), October 2008

Lawrence Baida Business Student Business Plan Winner, 2008

Lawrence Baida Business Student Business Concept Competition Winner, 2008

NASA Technology Transfer Award, 2008

Koerner Family Fellowship, 2007-2008

TERMIS Student Travel Award, NIH, November 2008

Drexel Student Outreach Award, 2008

TERMIS Student Travel Award, NIH, November 2007

GAANN Fellowship, Drexel University, 2006-2007

TERMIS Session Co-Chair Awardee, Metabolic Engineering, 2006

Dean’s Fellowship, Drexel University, 2006

Research Fellowship, Albert Einstein College of Medicine, 2002-2003

Benjamin Franklin Scholars Program, University of Pennsylvania, 1996-2000

Dean’s List, University of Pennsylvania, 1996-2000

West Jersey Hospital Volunteer Award for Community Service, 2000

 

ACTIVITIES:

 

§     Participated in the Summer Engineering Experience at Drexel (SEED) program and the Research Experience for Teachers (RET) program at Drexel. Activities involved mentoring high school students and high school teachers in advanced CAD technologies

§     Participated in Drexel University's Students Tackling Academic Research (STAR) Mentorship Program, Summer 2008

§     Participated in Summer High School Mentorship. Activities involved mentoring students in CAD modeling and cell culture techniques and biological assays

§     Co-advised Senior Design Students in their projects related to CAD, FEA, and RP

§     Participated in Drexel’s SquashSmarts to combine sport of squash with academic tutoring and mentoring of under-served urban youth to develop self-esteem and discipline through academic, athletic, and personal achievement

§     Position in Mechanical Engineering Graduate Association: Social Coordinator

§     Participated in FDA-sponsored Tissue Engineering Workshop on In Vitro Analyses of Cell/Scaffold Products, December 6-7, 2007

§     University of Pennsylvania Alumni Secondary School Committee Member

§     American Society of Cell Biology (ASCB) Member

 

CITIZENSHIP:      United States of America

 

 

 


REFERENCES:

  1. Dr. Wei Sun,

Albert Soffa Chair Professor,

Department of Mechanical Engineering and Mechanics, Drexel University,

3141 Chestnut Street, Philadelphia, PA 19104,

Email: sunwei@drexel.edu,

Tel: (215) 895 5810

 

  1. Dr. Alan C. Lau,

Professor and Department Chair,

Department of Mechanical Engineering and Mechanics, Drexel University,

3141 Chestnut Street, Philadelphia, PA 19104,

Email: lau@drexel.edu,

Tel: (215) 895 2377

 

  1. Dr. Selcuk Guceri,

Dean,

College of Engineering, Drexel University,

3141 Chestnut Street, Philadelphia, PA 19104,

Email: guceri@drexel.edu

Tel: (215) 895 2210

 

  1. Dr. Honglu Wu,

Manager, Biodosimetry Laboratory,

Human Adaptation and Countermeasures Division,

NASA Johnson Space Center, Houston, TX 77058,

Email: honglu.wu-1@nasa.gov

Tel: (281) 483-6470

 

  1. Dr. Robert Koerner,

Director and HL Bowman Professor Emeritus, Geosynthetic Institute,

475 Kedron Avenue, Folsom, PA 19033,

Email: robert.koerner@coe.drexel.edu

Tel: (610) 522 8440