Selected Publications


Pitcher J., Abt A., Myers J., Han R., Snyder M., Graziano A., Festa L., Kutzler M., Garcia F., Gao WJ, Fisher-Smith T., Rappaport J. and Meucci O. Neuronal ferritin heavy chain and drug abuse affect HIV-associated cognitive dysfunction. J Clin Invest. 2014, 124 (2):656-669. pii: 70090. doi: 10.1172/JCI70090. [Epub ahead of print]; PMID: 24401274

Pitcher J., Wurth R., Shimizu S, and Meucci O. Multispectral imaging and automated laser capture microdissection of human cortical neurons: a quantitative study of CXCR4 expression; Methods in Molecular Biology (2013) vol 1013; pp 31-48; DOI10.1007/978-1-62703-426-5_3.

  Chemokine Receptors and NeuroAIDS
  Chemokine Receptors and NeuroAIDS
Olimpia Meucci, Editor

Festa L. and Meucci O. Effects of Opiates and HIV Viral Proteins on Neurons: The Role of Ferritin Heavy Chain and a Potential for Synergism; invited review (peer-reviewed), Current HIV Research, 2012; 10(5):453-62, PMID: 22591369

Shimizu S., Brown M., Sengupta R., Penfold M., and Meucci O. CXCR7 protein expression in human adult brain and differentiated neurons . PLoS One. 2011; 6(5):e20680. Epub 2011 May 31; PMID: 21655198.

Abt Cook A. and Meucci O. Regulation of neuronal ferritin heavy chain, a new player in opiate-induced chemokine dysfunction (J. NeuroImmune Pharmacol, 2011; DOI 10.1007/s11481-011-9278-3)

Banerjee A., Strazza M. , Wigdahl B, Meucci O., and Nonnemacher MR. Role of mu-opioids as cofactors in human immunodeficiency virus disease progression and neuropathogenesis (J. Neurovirol. 2011)

Shimizu S., Abt A. and Meucci O. Bilaminar co-culture of primary rat cortical neurons and glia Journal of Visualized Experiments (JoVE), 2011 Nov 12;(57). doi:pii: 3257. 10.3791/3257

Burbassi S., Sengupta, and Meucci O. Alterations of CXCR4 function in the brain of MOR-deficient mice. European Journal of Neuroscience (2010), 32(8):1278-88. doi: 10.1111/j.1460-9568.2010.07402.x PMID: 20880358

Pitcher J., Shimizu S., and Meucci O., Disruption of neuronal CXCR4 function by opioids: preliminary evidence of Ferritin Heavy Chain as potential etiological agent in neuroAIDS Journal of Neuroimmunology (2010), 224:66-71

Khan MZ., Vaidya A., and Meucci O. CXCL12-mediated regulation of ANP32A/Lanp, a component of the Inhibitor of Histone Acetyl Transferase (INHAT) complex, in cortical neurons The Journal of Neuroimmune Pharmacology 2011 Mar;6(1):163-70, Epub ahead of print July 9 2010. PMID: 20617464.

Nicolai J. and Meucci O. “Homeostatic role of chemokines in the central nervous system: CXCL12 effects on developing and mature neurons”; in Chemokines: Types, Functions, and Structural Characteristics; Novascience Editions, (in press)

Nicolai J., Burbassi S., Rubin J., and Meucci O. CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a Histone deacetylase-dependent pathway contributing to neuronal survival Cell Death and Disease (2010) 1, e33; doi:10.1038/cddis.2010.10). [PDF file]

Cook A., Hippensteel R., Shimizu S, Nicolai J. Fatatis A. and Meucci O., Interactions between chemokines: regulation of fractalkine/CX3CL1 homeostasis by SDF/CXCL12 in cortical neurons J. Biol Chem (2010) 285:10563-71. [PDF file]

Busillo J., Armando S, Sengupta R, Meucci O., Bouvier M and Benovic J. Specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling J Biol Chem. (2010) 285:7805-17. [PDF file]

Sengupta R., Burbassi S., Shimizu S., Cappello S., Vallee R., Rubin J., and Meucci O. Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons. The Journal of Neuroscience (2009), 29(8). [PDF file]

Khan M.Z., Brandimarti R., Shimizu S., Nicolai J., Crowe E., and Meucci O, The chemokine CXCL12 promotes survival of post-mitotic neurons by regulating Rb protein. Cell Death & Differentiation (2008) 15:1663-1672. [PDF file]

Burbassi, S. Aloyo V, Chaijale N., Simansky K., and Meucci O. GTPgS incorporation in the rat brain: a study on m-opioid receptors and CXCR4, Journal of NeuroImmune Pharmacology (2008) 3:26-34. [PDF file]

Jamieson W., Shimizu S., D’Ambrosio J., Meucci O., and Fatatis A., CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/Fractalkine in the bone marrow: potential role in prostate cancer bone tropism, Cancer Research (2008) 68(6):1715-22. [PDF file]

Shimizu S, Khan MZ, Hippensteel R.L., Parkar A, Raghupathi, and Meucci O. “Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology”, Neurobiology of Disease 25: 17-26, (2007). [PDF file]

Bardi G, Sengupta G, Khan MZ, Patel JP and Meucci O., “HIV gp120-induced apoptosis of human neuroblastoma cells in the absence of CXCR4 internalization”, Journal of NeuroVirology 2: 211-218, 2006. [PDF file]

Patel JP, Sengupta R, Bardi G, Khan MZ, Mullen-Przeworski A., and Meucci O. “Modulation of neuronal CXCR4 by the µ-opioid specific agonist DAMGO” Journal of NeuroVirology 12:1-9, (2006). [PDF file] (Note: This PDF file is 17MB)

Khan M.Z, Shimizu S., Patel J., Nelson A., Le M-T., Mullen-Przeworski A., Brandimarti R., Fatatis A., and Meussi O. “Regulation of neuronal p53 activity by CXCR4”, Mol. Cell. Neurosci. 30(1):58-66, (2005). [PDF file]

Dolloff N.G, Shulby S.S., Nelson A.V, Stearns M.E., Johannes G.J, Thomas J.D., Meucci O., and Fatatis A. “Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha Platelet Derived Growth Factor Receptor”, Oncogene, 24:6848-6854 (2005). [PDF file]

Khan M.Z., Brandimarti R., Patel J.P., Huynh N., Wang J., Huang Z., Fatatis A., and Meucci O. Apoptotic and anti-apoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis. AIDS Research and Human Retroviruses 20:1063-71 (2004). [PDF file]

Shulby S.A, Dolloff N.G, Stearns M.E., Meucci O., and Fatatis A CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration and survival of human prostate cancer cells. Cancer Research, 64:4693-4698 (2004). [PDF file]

Brandimarti R., Khan M.Z., Fatatis A. and Meucci O. Regulation of cell cycle proteins by chemokine receptors: a novel pathway in HIV neuropathogenesis? Journal of NeuroVirology 10: 1-5 (2004). [PDF file]

Khan M.Z., Brandimarti R., Musser B.J., Resue D.M., Fatatis A., and Meucci O. The chemokine receptor CXCR4 regulates cell cycle proteins in neurons. Journal of NeuroVirology 9:300-314 (2003). [PDF file]

Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P, D'Adamio L. The γ-secretase-generated intracellular domain of β-amyloid precursor protein binds Numb and inhibits Notch signaling. PNAS 99:7102-7 (2002). [PDF file]

Meucci O., Fatatis A., Simen A.A., and Miller R.J. Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. PNAS 97: 8075-8080 (2000). [PDF file]

Miller R.J. and Meucci O. AIDS and the brain: is there a chemokine connection? Trends in Neuroscience 22:471-470, (1999). [PDF file]

Meucci O., Fatatis A., Simen A.A., Bushell T.J. Gray P.W. and Miller R.J. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. PNAS 95: 14500-505, (1998). [PDF file]

Meucci O. and Miller R.J. Dissociation between Joro spider toxin sensitivity of recombinant AMPA receptors and their ability to increase intracellular calcium Neuropharmacology 37:1431-1443 (1998).

Meucci O. and Miller R.J. gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective action of TGF-b1. J. Neurosci. 16:4080-4088 (1996).

Meucci O., Fatatis A., Holzwarth J. and Miller R.J., Developmental regulation of the toxin sensitivity of Ca2+ permeable AMPA receptors in cortical glia. J.Neurosci. 16:519-530 (1996). [PDF file]

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