Lipoprotein Separation in Nanoscale Architectures
Many people around the world suffer from high cholesterol associated with high levels of low density lipoproteins (LDL). Current techniques to deal with this condition include prescription medication like statins or a more direct approach like LDL apheresis. Both these techniques are potentially harmful and expensive. We propose to use solid state nanopore based architectures to carry out cheap, safe and efficient LDL apheresis without the introduction of any potentially harmful chemicals. In a proof of concept experiment, involving nanoparticles that closely resemble plasma lipoproteins we have shown how electrokinetic interactions between the nanoparticles and the surface of the nanopore can separate the LDL like particles from the HDL like particles. We are currently investigating ways to increase the efficiency of separation and develop a high throughput device based on this mechanism.
Collaborators: Prof. Prashanta Dutta @ WSU
