2017 Winter Chemistry seminar schedule and videos (click the link)

 

The following is the schedule for Seminars 2017-2018 Winter, but it is subject to changes.

 

Date

Name

From

Host faculty

Title

1/11

Andrew Hejl

Dow Chemical

Fraser Fleming

 

1/18

Michael Thompson

Univ. Toronto

Jun Xi

Anti-fouling acoustic wave and electrochemical biosensor technology

1/25

 

 

 

 

2/1

Tina Ross

Univ. West Chester

Dionicio Solorio

A Selective Small Molecule Nociceptin Receptor (NOP) Agonist for the Treatment of Anxiety Disorders

2/8

Karl Booksh

U. Deleware

Hoffman Lee

Raman Hyper-Spectral Imaging of Meteorites, Meteorite Impacts, and a Little Bit of Art

2/15

Dan Reasoner

Scifinder

Department

 

2/22

 

 

 

 

3/1

minisymposium

Drexel University

 

 

3/8

Minisymposium

Drexel Univ

 

 

3/15

Norman

Notre Dame

Joe Foley

 

 

1/11   11:00pm, Disque 109

Speaker: Michael Thompson, BSc, PhD, DSc, FRSC (UK), FRSC (Canada), FCIC, CChem Department of Chemistry and Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, M5S 3H6, CANADA

mikethom@chem.utoronto.ca

Title: Anti-fouling acoustic wave and electrochemical biosensor technology

Abstract: Our research concerns the development of a chemipassive surface that is being employed to modify both the surface of biosensors and other devices used in medicine.  The interaction of substrates with the components of biological fluids, especially blood, has constituted a research problem over many years. In this regard, a variety of strategies have been used to attempt an enhancement of biocompatibility with some emphasis being centered on the imposition of a plethora of surface coatings. In our work we are addressing the physical chemistry of covalent surface modification through the synthesis of new silane-based molecules. These moieties are bifunctional, medium-chain length trichlorosilanes containing a PEG backbone. (PEG has been the subject of intense study for many years). Given that strategies for enhanced biocompatibility and anti-fouling of biosensors share much common ground, we applied our surface modification in both fields. In particular, we have applied the anti-fouling approach to the acoustic wave detection of endotoxin in human plasma and cancer biomarkers in serum, and K+ concentration in brain-based fluid. With regard to the former, a qualitative, cut-off (mid pg per mL) biosensor assay alternative for bacterial endotoxin has been developed based on the acoustic wave physics of the highly sensitive, ultra-high frequency electromagnetic piezoelectric acoustic sensor (EMPAS) transducing device. Secondly, in collaboration with Electrical Engineering at the University of Toronto and the Krembil Institute (Western Hospital) Toronto we have fabricated a multichannel monolayer coated gold microelectrode for in vivo spatio-temporal measurements of [K+]o in a mouse brain as an improvement to the more conventional glass capillary electrode. The performance of the device is critically dependent on the aforementioned anti-fouling surface modification used in tandem with a new probe for potassium. Finally we are now employing the anti-fouling chemistry in a search for an assay for the early stage detection of ovarian cancer. This is based on biosensor detection of two biomarkers for the disease directly in human serum, HSP10 and lysophosphatidic acid.

 

2/1 11:00 am, Disque 109

Speaker: Tina Morgan Ross, Johnson & Johnson Pharmaceutical Research and Development, LLC, Spring House, PA USA. West Chester University, Chemistry Department, West Chester, PA USA. e-mail: tross@tindeytech.com

Title: A Selective Small Molecule Nociceptin Receptor (NOP) Agonist for the Treatment of Anxiety Disorders

Abstract: Research will be presented on Nociceptin receptor (NOP) agonists for the treatment of anxiety related disorders.1 NOP is a member of the opioid subfamily that has homology to other opioid receptors; however it is uniquely different.2 Using a molecular diversity approach, we were able to rapidly advance a library of compounds for biological testing. Through iterative design and analysis of structure activity results, we were able to improve selectivity for NOP over Mu opioid receptor and discover full NOP agonists. A selective (132-fold NOP/Mu) full agonist JNJ- 19385899, compound (1) progressed to clinical studies. The design strategy, synthetic approach and biological data for the related chemical series will be presented.

 

Seminar series:

Chemistry: http://www.drexel.edu/chemistry/news/events/

Physics: http://www.drexel.edu/physics/news/colloquia/

 

Biology: http://www.drexel.edu/biology/calendar.html

 

Materials Science and Engineering (MSE):

http://www.materials.drexel.edu/events/seminars/

 

 

Mechanical Engineering and Mechanics (MEM): http://www.mem.drexel.edu/seminars/

 

Biomedical Engineering: http://www.biomed.drexel.edu/new04/Content/news_events/

 

Electrical and Computer Engineering (ECE):  http://www.ece.drexel.edu/ECECalendar.html

Chemical Engineering: http://www.chemeng.drexel.edu/news/2008/december/winterseminarseries/Default.aspx

 

Civil, Architectural and Environmental Engineering (CAEE)

http://www.cae.drexel.edu/seminars.asp

 

Complete list of engineering: http://drexel.edu/engineering/news/seminars/