Welcome to our website!
This website was developed with numerous things in mind. We wished to offer novice immunologists a chance to explore the wonders of tissue and organ transplantation in a concise, easy-to-understand fashion. We wished to provide the history of transplantation back to 800B.C. in India. This site offers the biochemical foundation on which the varying types of transplantation are founded. In addition to exploring the various types of transplantation that are available today, we shall investigate the challenges facing transplant recipients in the form of tissue and organ rejection, that too comes in a variety of forms. Lastly, with so many obstacles to overcome to make a transplant work, what advances has the medical community made to prolong these lifesaving biotechnological marvels?
Transplantation is not only important in saving human lives but helps provide an immense understanding of the immune system. Due to the study of mouse skin-graft rejections, the discovery of the entire MHC was made possible. T-cells are also the most important cells involved in transplant rejection. All of the knowledge of T-cells is pretty much derived from transplantation. The need to stop transplant rejection has also led to immunosuppressive drugs, which can also be used in other ways that are more general than just transplantation -- including hypersensitivity or autoimmunity.
Nearly all aspects of Immunological Function occurred during transplantation
Organ transplantation is meant to prolong life by replacing organs whose lifespan is already over. Since the replacement organs are not from the same person (as in an autograft), the organ will be recognized as foreign and illicit an immune response. The immune response stimulated is both specific and non-specific and the problem is largely due to the fact that the T-cells have foreign peptide antigens presented from the MHC molecules on the grafted cells. A transplant can activate all the regulatory mechanisms that control regulatory responses.