Exploring and expanding our understanding of cell motility through cutting edge 3d imaging

Even when we are standing still, the cells in our bodies are going places. It is now clear that an individual cell can change how it moves in response to the material surrounding it. My lab is interested in understanding how the structure of the three-dimensional (3D) extracellular matrix dictates the molecular and physical mechanisms driving cell motility.

Specialization: Live cell imaging and cellular movement

biosights: May 14, 2012 - A new way forward for fibroblasts

  • View on YouTube
  • Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge

biosights: January 2 2017 - Tumor cells feel the pressure after protease inhibition

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  • Primary fibroblasts use a high pressure, “nuclear piston” mode of migration to move through highly cross-linked 3D extracellular matrices

Ryan Petrie

Ryan Petrie Ph.D.

  • Assistant Professor
  • Principal Investigator