PUBLICATIONS:

Archival/refereed papers after tenure-track appointment (September 2003 - present)

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  3. Layton, B.E., Sastry, A.M., “An Equal and Local-Load-Sharing Failure-Mechanics Model for Peripheral Nerve Extracellular Matrix in Diabetic and Non-Diabetic Rats.” in review for Acta Biomaterialia
  4. Singh, R., Gadia, V., Roy, S., Venkatesh, N., Lunagaria, S., Patel, R., Layton, B.E. “Towards Nanotechnology for All” News from the Bottom, Volume 1, Issue 2. http://schc.sc.edu/nfb/NFBIssues.lasso
  5. Singh, R., Gadia, V., Roy, S., Venkatesh, N., Lunagaria, S., Patel, R., Layton, B.E. “Construction of an Educational Model of an Atomic Force Microscope.” The Nanotechnology Group Volume 4, Number 7. http://www.thenanotechnologygroup.org/index.cfm?content=79
  6. Layton, B.E., Sullivan, S.M., Palermo, J.J., Buzby, G.J., Gupta, R., Stallcup III, R.E., 2005. “Nanomanipulation and Aggregation Limits of Self-Assembling Structural Proteins,” MicroElectronics Journal 36 (7) 644-649.
  7. Layton, B.E., Sastry, A.M., 2004. “A Mechanical Model for Collagen Fibril Load Sharing in the Peripheral Nerve of Diabetic and Non-Diabetic Rats.” ASME Journal of Biomechanical Engineering 126, 803-814.
  8. Layton, B. E., Sastry, A. M., Lastoskie, C. M., Philbert, M. A., Miller, T. J., Sullivan, K.A., Feldman, E.L., Wang C.-W., 2004. “In Situ Imaging of Mitochondrial Outer Membrane Pores Using Atomic Force Microscopy.” Biotechniques 37, 564-573.
  9. Layton, B.E., Sastry, A.M., Sullivan, K.A., Feldman, E.L., Wang, H., Philbert, M.A., Komorowski, T.E., 2004. “Differences between Collagen Morphologies, Properties and Distribution in Diabetic and Normal BioBreeding and Sprague-Dawley Rat Sciatic Nerves.” Journal of Biomechanics 37 (6) 879-888.
  10. Wang, H., Layton, B.E., Sastry, A.M., 2003. “Nerve Collagens from Diabetic and Non-diabetic Sprague-Dawley and BioBreeding Rats: An Atomic Force Microscopy Study.” Diabetes Metabolism Research and Reviews 19 (4) 288-298.
  11. Cheng, X., Sastry, A.M., Layton, B.E., 2001. “Transport in Stochastic Fibrous Networks.” Journal of Engineering Materials and Technology 123 (1) 12-19.
Journal papers in progress:
Mitchell, D., Tocco, M., Layton, B.E. “Knanoknot” in preparation for Science

Sabur, A., Layton, B.E. “Spectroscopic Comparison of Trichodesmium Collagen with Vertebrate Collagen” in preparation for Nature

Borgmann, J., Booker, G., Silverstein, S., Layton, B.E. “A Novel Multiscale Hypothesis for the Translation Optimization of Collagen” in preparation for Nature

Patel, R., Layton, B.E., “Parameter Optimization of Piezoelectrically Driven Multiaxis Nanopositioners” in preparation for Nanotechnology

Layton, B.E., Chenevert, T.L. “A Temporal Compartmental Model for Brain-Tumor Volume and Apparent Diffusion Coefficient Changes in Response to Treatment.” in preparation for Magnetic Resonance in Medicine

Allen K., Zeiger, A. Layton, B.E., “A Mechanics-Based Model for Microtubule Assembly and Axonal Transport” in preparation for Journal of Cell Biology

Sullivan, S.M., Layton, B.E., Jamieson, B.G., A Space-Based Electrical Impedance Hematology Analyzer, in preparation for Lab on a Chip.

Sasoglu, F.M. Layton, B.E. “A microfabricated PDMS microbeam array for parallel piconewton force transduction.” in preparation for ASME Transactions

Application notes:

11. Rishi Gupta, Aaron Geisberger, Gareth Hughes (Zyvex Corporation), Dr. Brad Layton (Drexel University), Zyvex Application Note 9710: “Manipulation of Collagen for Mechanical Characterization” http://www.zyvex.com/Products/CFMC_001a.html http://www.zyvex.com/Documents/9710.PDF

Conference papers published:

12. Sullivan, S.M., Jamieson, B.J., Layton, B.E., “A Micro-Fabricated Electrical Impedance Based Hematology Analyzer,” ASME International Mechanical Engineering Congress and Exposition. November 5-11, 2005, Orlando, FL

13. Allen, K.B., Sasoglu, F.M., Layton, B.E., “Mechanical Neural Growth Models,” ASME International Mechanical Engineering Congress and Exposition. November 5-11, 2005, Orlando, FL

14. Layton, B.E., Jamieson, B.J., Sullivan, S.M. 2005. “A Micro-Fabricated Electrical-Impedance-Based In-Flight Hematology Analyzer,” 3rd Annual Conference on Microchannels and Minichannels. June 13-15, Toronto, Canada.

15. Layton, B.E., Allen, K.B., Stokes, M.D., Myers, K.A., Baas, P.W., 2005. “Towards a Method for Peripheral Nervous System Axonal Stiffness Measurements with MEMS-based Microgrippers,” 2nd Annual IEEE-EMBS Conference on Neural Engineering, March 16-19, Arlington, VA.

16. Layton, B.E., Fontecchio, A., Ko, F., Nabet, B., Spanier, J. 2005. ”Acquisition of a Zyvex L100 nanomanipulation device for biological, electronic, and optoelectronic samples and devices.” Design, Service and Manufacturing Research and Grantees Conference, Jan 3-6.Tempe, AZ

17. Layton, B.E. 2004. “Nanomanipulation and Aggregation Limits of Self-Assembling Structural Proteins” European Micro and Nano Systems, October 20-21, Paris France

18. Layton, B.E. 2004. “Self-Assembly Limits in Structural Proteins” Proceedings of ASME Integrated Nanosystems, September 22-24, Pasadena, CA

19. Layton, B.E., Gupta, R., Jackson, N.L., Shah, A.J., Stallcup, R.E., III, Sullivan, S.M., 2004. “Nanomanipulation and Characterization Of Structural Proteins” 26th Annual International Conference IEEE-EMBS Sep 1-5, Francisco, CA.

20. Layton, B.E. 2004 “A Mechanics-Based Model for the Collagen Fibril Aggregation Limit” October 13-16, 2004, Biomedical Engineering Society Annual Fall Meeting, Philadelphia, PA

21. Layton, B.E. Sastry, A.M., 2003. Mitochondrial Pore Imaging via AFM. BMES Annual Fall Meeting. Oct 1-4, Nashville, TN.

22. Layton, B.E. 2003. Implications of hexagonal close-packing in a finite domain on self-assembly of nanofibrous materials. NATO-Advance Study Institute (ASI) Nanoengineered Nanofibrous Materials. Sep 1-12, Antalya Turkey.

23. Chenevert, T.L., Layton, B.E., Johnson, T.D., Schepkin, V.D., Ross, B.D. 2003. A Model of Temporal Dependence in Therapy-Induced ADC Change, ISMRM 11th Scientific Meeting and Exhibition, Toronto July 10-16.

24. Layton, B.E., Sastry, A.M., 2002. Damage in the heterogeneous ECM of peripheral nerves due to diabetes. ASME International Mechanical Engineering Congress, November 17-22, New Orleans, LA.

25. Layton, B.E., Sastry, A.M., Wang, H., Sullivan, K.A., 2002. A model for pressure enhancement in the diabetic nerve: simulations of diabetic rat peripheral nerve and nerve collagens. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] EMBS/BMES Conference, 2002. Proceedings of the Second Joint, Volume: 1, 450 -451.

26. Sastry, A.M.; Layton, B.E.; Wang, H.; Sullivan, K.A.; Philbert, M.A.; Komorowski, Mechanical and structural changes in diabetic rat peripheral nerve collagens Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, v 1, 2002, p 432-433

27. Layton, B.E., Sastry, A.M., Sullivan, K.A., Feldman, E.L., 2000. Remodeling of Peripheral Nerve Tissue in Diabetic Rats. International ASME Congress, November 5-10, Orlando, FL

Patents and Provisional Patents:

1. “A Pontoon Rowing Boat for Children” (provisional patent, November 29, 2005)

2. “An Integrated Atomic Force Microscopy Nanomanipulation Platform” (provisional patent, November 29, 2005)

SEMINARS, LECTURES, WORKSHOPS, INVITED TALKS AND PRESENTATIONS

After tenure-track appointment (from September 1, 2005 – present)

1. “Nanometrology and Micrometrology of Cells, Organelles and Proteins under Mechanical and Environmental Challenge” December, 2005. invited speaker at the Army Research Laboratory

2. "Nanometrology and Micrometrology in Biological Systems" November, 2005. invited speaker at the National Institute of Standards and Technology, Mathematical and Computational Sciences Division

3. “An update of the micromanipulation and nanomanipulation capabilities at Drexel University.” July, 2005. invited speaker at the Drexel University GPBA Bio-Nanotechnology Symposium

4. “Micromanipulation, Nanomanipulation and Self-Assembly Limits of Structural Proteins” February, 2005. invited speaker at the Drexel University Department of Material Science and Engineering

5. “Nanotechnology meets Neuroscience” February, 2005. invited Neurology Grand Rounds speaker at the Drexel University School of Medicine

6. “Micromanipulation, Nanomanipulation and Self-Assembly Limits of Structural Proteins”November, 2004. invited speaker at the Drexel University Department of Biomedical Engineering, Science and Health Systems

7. “Nanomanipulation and Characterization of Structural Proteins” November, 2004. invited speaker at the Computational Systems Biology Group sponsored by Aydin Tozeren

8. “Nanoscopic Imaging and Nanomanipulation of Neurons, Organelles, and Proteins” July, 2004. invited speaker at Drexel Queen Lane Campus laboratories of Dr. Peter Baas on neuronal manipulation

9. “Cellular Nanomanipulation: Cell Sensing Series” June, 2004. invited seminar speaker at Drexel Biochemistry Department IBAPS Institute of Basic and Applied Protein Science,

10. “Mechanical Models of Soft Tissue: Molecular to Tissue Scales” October, 2003. invited seminar speaker at Drexel Department of Material Science Department.

Conference Poster Presentations

1. Sullivan, S.M., Layton, B.E., Jamieson, B.G. Velasquez, J. 2005. “A Micro-Fabricated Electrical-Impedance-Based In-Flight Hematology Analyzer,” BMES Fall Meeting, Baltimore, MD, September 29, 2005.

2. Sasoglu, F.M. Layton, B.E., 2005. “Parameterization and Microfabrication Procedure of A Microcone Array to Measure Cell Stiffness,” BMES Fall Meeting, Baltimore, MD, September 29, 2005.

3. Allen, K.B., Layton, B.E., 2005 “Mechanical Neural Growth Models” BMES Fall Meeting, Baltimore MD September 29 2005.

4. Allen, K.B., Layton, B.E., 2005. “Microtubule Polymerization, and Single Cell Micromanipulation,” A.J. Drexel Institute of Basic and Applied Protein Science 3rd Annual Protein Institute Retreat, June 16th 2005

5. Sasoglu, F.M., Layton, B.E., 2005. “A Silicone Elastomer Microbeam Array for Measuring Neurite Stiffness,” Drexel University Research Day, April 26, 2005, Philadelphia, PA.

6. Sullivan, S.M., Layton, B.E., Jamieson, B.J., 2005 “A Micro-Fabricated, Electrical-Impedance-Based Space-Based Hematology Analyzer,” Drexel University Research Day, April 26, 2005, Philadelphia, PA.

7. Layton, B.E., Fontecchio, A., Ko, F.K., Nabet, B., Spanier, J.E., Luzzi, D., MacDiarmid, A., Allen, K.B., Ermold, M., Gallo, E., Laim, L., Sullivan, S.M. Titchenal, N., 2005. “Acquisition of a nanomanipulation device for biological, electronic, and optoelectronic samples and devices” National Science Foundation Design, Service, and Manufacturing Research and Grantees Conference, January 3-6, 2005, Scottsdale, AZ,

8. Sullivan, S.M. Layton, B.E. 2004 “Genomic Sequence Analysis of Structural Proteins as a Predictor for Tissue Properties” Biomedical Engineering Society Annual Fall Meeting, Oct 13-16, 2004, Philadelphia, PA.

9. Jackson, N.L., Sullivan, S.M., Layton, B.E. 2004. “’Knanoknot’ Nanomechanical Manipulation of Collagen fibrils” Biomedical Engineering Society Annual Fall Meeting, Oct 13- 16, 2004, Philadelphia, PA.

10. Rose, S., Tan, S., Azad, F., Layton, B.E. 2004. “A self-assembly model for genetically engineered collagen” Biomedical Engineering Society Annual Fall Meeting, Oct 13-16, 2004, Philadelphia, PA

11. Stokes, M., Layton, B.E., 2004 “Nanotechnology - Thermally Activated microgrippers” Biomedical Engineering Society Annual Fall Meeting, Oct 13-16, 2004, Philadelphia, PA

12. Palermo, J.P., Buzby, G., Allen, K., Hudson, J., Hubert-Theriot, J., Layton, B.E. 2004. “Bench Top Atomic Force Microscope” Biomedical Engineering Society Annual Fall Meeting, Oct 13-16, 2004, Philadelphia, PA.

13. PA Shah, A.J., Layton, B.E., 2004. “Assessment and Design of MEMS Microgripper Technologies,” Drexel University Research Day, May 4, 2004, Philadelphia, PA.

14. Sullivan, S.M., Layton, B.E., 2004. “Directed Evolution of Earth’s Most Abundant Protein,” Drexel University Research Day, May 4, 2004, Philadelphia, PA.

15. Jackson, N.L., Layton, B.E., 2004. “KnanoKnot” – Nanomechanical Manipulation of Collagen Fibrils,” Drexel University Research Day, May 4, 2004, Philadelphia, PA.

16. Ramacrishna, P., Layton, B.E., 2004. “Towards Building a Molecular Rope Using Molecular Dynamics,” Drexel University Research Day, May 4, 2004, Philadelphia, PA.

17. “A Mathematical Model of Apparent Diffusion Coefficients in Brain Tumor Magnetic Resonance Imaging” July, 2003. presentation of postdoctoral research on brain tumor response modeling to Radiology Department, University of Michigan

18. “Nanoscopic Mitochondrial Imaging” June, 2003. presentation of postdoctoral research on mitochondrial imaging results to Neurology Department, University of Michigan

 

 

 

 

Bradley Edward Layton | Research | Publications | Teaching | People | Lab Tour | Resources
 
Department of Mechanical Engineering and Mechanics
 Room 151G Curtis Hall, 3141 Chestnut Street, Philadelphia, PA 19104-2884
 Email: blay@drexel.edu
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