Selected Publications

1. Jamieson WL, Zhang Y, Fong AM, Meucci O, and Fatatis A. The chemokine receptor CX3CR1 is directly involved in the arrest of breast cancer cells to the skeleton. Breast Cancer Research (Published On-line first) (2011).
   
   
2. Liu Q., Jernigan D., Zhanh, Y., and Fatatis A. Implication of platelet-derived growth factor receptor alpha in prostate cancer skeletal metastasis. Chinese J. Cancer 30, 612-619 (2011). [PDF]
   
   
3. Russell MR, Liu Q and Fatatis A. Targeting the alpha receptor for Platelet-Derived Growth Factor as a primary or combination therapy in a preclinical model of prostate cancer skeletal metastasis. Clinical Cancer Research 16, 5002-5010 (2010). – Cover Article –. [PDF]
   
   
4. Russell MR, Liu Q, Lei H, , Kazlauskas A, and  Fatatis A.  The alpha receptor for platelet derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms. Cancer Research 70, 4195-4203, (2010). [PDF]
   
   
5. D'Ambrosio J.A. and Fatatis A. Osteoblasts modulate Ca²⁺ signaling in prostate and breast cancer cells with bone-metastatic potential. Clinical and Experimental Metastasis 26, 955-964, (2009). [PDF]
   
   
6. Russell M.R., Jamieson W.L., Dolloff N.G. and Fatatis A. The alpha receptor for Platelet Derived Growth Factor as a target for antibody-mediated inhibition of skeletal metastases from prostate cancer cells. Oncogene 28, 412-421, (2009). [PDF]
   
   
7. Jamieson W.L.. Shimizu S., D’Ambrosio J.A., Meucci, O. and Fatatis A. CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/Fractalkine in the bone marrow: potential role in prostate cancer bone tropism. Cancer Research 68 1715-1722. (2008). [PDF]
    
8. Dolloff N.G., Russell M.R., Loizos N. and Fatatis A. Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the alpha Platelet-derived Growth factor receptor. Cancer Research 67 555-562. (2007). [PDF]
    
9. Dolloff N.G., Shulby S.A., Nelson A.V., Stearns M.E., Johannes G.J., Thomas J.D., Meucci O., and A. Fatatis. Bone metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha-Platelet-Derived Growth Factor Receptor. Oncogene 24, 6848-6854, (2005). [PDF]
    
10. Shulby, S.A., Dolloff N.G., Stearns M.E., Meucci O. and A. Fatatis. CX3CR1-Fractalkine expression regulates cellular mechanisms involved in adhesion,migration and survival of human prostate cancer cells. Cancer Research 64, 4693-4698 (2004). [PDF]
     

Collaborative Studies and Other Publications

1. Cook A, Hippensteel R, Shimizu S, Nicolai J, Fatatis A, Meucci O. Interactions between chemokines: regulation of fractalkine/CX3CL1 homeostasis by SDF/CXCL12 in cortical neurons. J Biol Chem. 285, 10563-10571, (2010).
   
   
2. Khan MZ, Shimizu S, Patel JP, Nelson A, Le MT, Mullen-Przeworski A, Brandimarti R, Fatatis A, Meucci O. Regulation of neuronal P53 activity by CXCR4. Molecular and Cellular Neurosciences 30, 58-66 (2005). [PDF]
    
3. Khan M.Z., Brandimarti R., Patel J.P., Huynh N., Wang J., Huang Z., Fatatis A., Meucci O. Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis. AIDS Res Hum Retroviruses 20, 1063-71 (2004) [PDF]
    
4. Brandimarti, R., Khan M.Z, Fatatis A. and O. Meucci. Regulation of cell cycle proteins by chemokine receptors: A novel pathway in human immunodeficiency virus neuropathogenesis? Journal of Neurovirology 10, 108-112 (2004). [PDF]
    
5. Khan M.Z., Brandimarti R., Musser B.J., Resue D.M., Fatatis A. and O. Meucci. The chemokine receptor CXCR4 regulates cell-cycle proteins in neurons. Journal of Neurovirology 9, 300-314 (2003). [PDF]
    
6. Meucci, O., Fatatis, A, Simen A.A. and R.J. Miller. Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proceedings of The National Academy of Sciences, USA 97, 8075-8080, (2000) [PDF]
    
7. Fatatis, A. and R.J. Miller. Cell cycle control of PDGF-induced Ca²⁺s signaling through modulation of sphingolipid metabolism. FASEB Journal, 13, 1291-1301, (1999) [ PDF]
    
8. Meucci, O., Fatatis, A., Simen, A.A., Bushell, T.J., Gray, P.E. and R.J., Miller. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proceedings of The National Academy of Sciences, USA 95, 14500-14505, (1998) [ PDF]
    
9. Fatatis, A. and R.J. Miller. PDGF-induced Ca²⁺ signaling in the CG4 oligodendroglial cell line and in transformed oligodendrocytes expressing the b-PDGF receptor. Journal of Biological Chemistry 272, 4351-4358, (1997) [ PDF]
    
10. Fatatis A. and R.J. Miller. Sphingosine and sphingosine-1-phosphate differentially modulate PDGF-BB induced Ca²⁺ signaling in transformed oligodendrocytes. Journal of Biological Chemistry 271, 295-301, (1996) [ PDF]
     
11. Meucci O., Fatatis A., Holzwarth J. and Miller R.J., Developmental regulation of the toxin sensitivity of Ca²⁺ permeable AMPA receptors in cortical glia. Journal of Neuroscience 16:519-530 (1996) [PDF]
     
12. Fatatis A., L.A. Holtzclaw, R. Avidor, D.E. Brenneman and Russell JT. Vasoactive intestinal peptide increases intracellular calcium in astroglia: synergism with alfa-adrenergic receptors.
    Proceedings of The National Academy of Sciences, USA 91:2036-2040, (1994) [PDF]
     
13. Fatatis A., Caporaso R., Iannotti E., Bassi A., Di Renzo G.F. and Annunziato L. Relationship between time of activation of phospholipase-C linked plasma membrane receptors and reloading of intracellular Ca²⁺ stores in LAN-1 human neuroblastoma cells. Journal of Biological Chemistry 269: 18021-18027, (1994) [PDF]
     
14. Savarese D. M. F., J.T. Russell, A. Fatatis and L.A. Liotta. Type IV collagen stimulates PTX-insensitive increase in intracellular calcium: potential role in tumor cell motility. Journal of Biological Chemistry 267: 21928-21935, (1992) [ PDF]